COBRA - Chimie organique et bioorganique - réactivité et analyse

Application areas

• Pharmaceutical industry
• Cosmetics
• Energy
• Agri-food
• Environment

Know-how and expertise

Analysis and modeling
Molecular and supramolecular mass spectrometry, NMR and molecular modeling, theoretical chemistry.

Organicandorgano-metallic synthesis
Organo (bi) metals in enantioselec- tive synthesis, carbometalation of alkenes and alkynes, organome- tallic, organocatalytic and natural product synthesis methodologies, continuous organic synthesis and reactivity, organic synthesis under ultra high pressure.

Bioorganic chemistry
Chemistry of organic fluorophores, probe for imaging, medicinal chemistry and reactivators, immunoenzymatic detection of toxins, synthetic methodology.

Fluorinated biomolecules synthesis
New methods of synthesis in organofluorinated chemistry, elaboration and synthesis of fluorinated biomolecules.

Heterocycles
Pharmacochemistry of heterocycles, direct functionalization of the C-H bond of heterocycles, organocatalysis.

Facilities

Advanced equipment

• 6 NMR: 600 MHz, 500 MHz, 400 MHz and 3 x 300 MHz
• Mass Spectrometry: FT-ICR ultra-high resolution, Q-IM-TOF- MS, MALDI-TOF-MS, LC-MSMS, GCMS ...
• ICP-MS
• equipment for continuous flow and microfluidic synthesis
• high pressure devices ...

A wide range of collaborations

tific success of the laboratory and more than 50 patents have been filed since its creation. COBRA is also the winner of an ERC. The skills of COBRA are widely exported: Germany, England, Italy, Spain, Switzerland, United States, Japan ...